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Title Recombinant human erythropoeitin (rhEPO) in clinical oncology : scientific and clinical aspects of anemia in cancer / Mohammad Resa Nowrousian (ed.)
Edition 2nd, rev. and enl. ed
Published Wien ; New York : Springer, ©2008

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Description 1 online resource (xviii, 866 pages) : illustrations
Contents Title Page; Copyright Page; Preface; Table of Contents; Contributors; Chapter 1 Physiology of erythropoiesis; Ontogenesis of erythropoiesis; Basic mechanisms in the control of erythropoiesis; Role of EPO, EPO-R, Kit Ligand and c-kit in the control of erythropoiesis; Molecular mechanisms of control of erythropoiesis: role of transcription factors; Anti-apoptotic mechanisms operating in erythroid cells; Role of apoptosis in the control of erythropoiesis; Role of AKT pathway in the apoptotic control of the erythroid lineage
Further signaling pathways involved in the apoptotic regulation of erythroid cellsSummary; References; Chapter 2 Biology of EPO and EPO-receptor; Introduction; Role of EPO in erythropoiesis; Regulation of EPO production; Structure of the EPO receptor; EPO-induced intracellular signalling; Pathways leading to signalling arrest; Acknowledgements; References; Chapter 3 The role of erythropoietin receptor expression on tumor cells; Introduction; Does EPO cause proliferation of tumor cells in vitro?; What does the detection of EPO receptors on tumor cell mean?; Concluding remarks; Acknowledgements
Hematological characteristicsShortened red blood cell survival; Impaired iron utilization; Suppressed erythroid progenitor cells; Inadequate erythropoietin production; Summary; References; Chapter 7 Prevalence and incidence of anemia and risk factors for anemia in patients with cancer; Definition of anemia; Anemia in cancer; Prevalence of anemia in cancer; Risk factors for prediction of anemia; Acknowledgement; References; Chapter 8 Significance of anemia in cancer chemotherapy; Introduction; Incidence; Pathophysiology; Predictive factors; Prognostic significance; Conclusion; References
Chapter 9 Incidence and impact of anemia in radiation oncologyIntroduction; Frequency of anemia; Prognostic impact of anemia; Explanations for the prognostic impact of anemia; References; Chapter 10 Relationship between hemoglobin levels and tumor oxygenation*; Introduction; Tumor hypoxia and anemia as adverse prognostic factors; Relationship between hemoglobin level and tumor oxygenation: animal studies; Relationship between hemoglobin level and tumor oxygenation: clinical observations; Conclusions; Addendum; Acknowledgement; References; Chapter 11 Tumor hypoxia and therapeutic resistance*
Summary Anemia, a frequent complication of cancer and its treatments, produces unwanted symptoms and significantly impairs metabolic and physiologic functions, as well as patients' activity, quality of life and even life expectancy. In its new Second Edition, this book presents current knowledge on anemia in cancer and its treatment with Recombinant Human Erythropoietin (rhEPO). Expanded, updated and newly added chapters describe scientific and clinical aspects of anemia, and give diagnostic and therapeutic recommendations on use of rhEPO. This is an essential source of information for radiotherapists
Analysis geneeskunde
medicine
volksgezondheid
public health
radiotherapie
radiotherapy
hematologie
haematology
chirurgie
surgery
farmacologie
pharmacology
toxicologie
toxicology
bloedtransfusie
blood transfusion
oncologie
oncology
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Recombinant erythropoietin -- Therapeutic use
Anemia -- Chemotherapy
Cancer -- Chemotherapy -- Complications.
Anemia -- physiopathology
Erythropoietin, Recombinant -- therapeutic use
Anemia -- complications
Erythropoietin -- therapeutic use
Neoplasms -- complications
Anemia -- Chemotherapy
Cancer -- Chemotherapy -- Complications
Recombinant erythropoietin -- Therapeutic use
Form Electronic book
Author Nowrousian, M. R
ISBN 9783211694596
3211694595
3211252231
9783211252239