| Description |
1 online resource (xix, 601 pages) : illustrations, portrait |
| Contents |
History of angiogenesis / Judah Folkman -- Section I. Physiological & pathological angiogenesis : biology of the angiogenic process. Angiogenesis and vascular remodeling in inflammation and cancer : biology and architecture of the vasculature / Donald M. McDonald ; Endothelial cell activation / M. Luisa Iruela-Arispe ; Pericytes, the mural cells of the microvascular system / Gabriele Bergers ; Matrix metalloproteinases and their endogenous inhibitors / Liliana Guedez and William G. Stetler-Stevenson ; Integrins in angiogenesis / Alireza S. Alavi and David A. Cheresh -- Section II. Angiogenesis and regulatory proteins. Fibroblast growth factor-2 in angiogenesis / Marco Presta, Stefania Mitola, Patrizia Dell'Era, Daria Leali, Stefania Nicoli, Emanuela Moroni, and Marco Rusnati ; Vascular permeability/vascular endothelial growth factor / Masabumi Shibuya ; Platelet-derived growth factor / Andrius Kazlauskas ; Angiopoietins and tie receptors / Pipsa Saharinen, Lauri Eklund, and Kari Alitalo ; Basement membrane derived inhibitors of angiogenesis / Michael B. Duncan and Raghu Kalluri ; Angiostatin and endostatin : angiogenesis inhibitors in blood and stroma / Judah Folkman ; Thrombospondins : endogenous inhibitors of angiogenesis / Paul Bornstein -- Section III. Molecular & cellular mechanisms of the angiogenic process. Overview of angiogenesis during tumor growth / Domenico Ribatti and Angelo Vacca ; Hypoxic regulation of angiogenesis by HIF-1 / Philip J.S. Charlesworth and Adrian L. Harris ; Regulation of angiogenesis by von Hippel Lindau protein and HIF2 / Donald P. Bottaro, Nelly Tan, and W. Marston Linehan ; Nitric oxide in tumor angiogenesis / L. Morbidelli, S. Donnini, and M. Ziche ; VEGF signal tranduction in angiogenesis / Harukiyo Kawamura, Xiujuan Li, Michael Welsh, and Lena Claesson-Welsh ; Delta-like ligand 4/notch pathway in tumor angiogenesis / Gavin Thurston, Irene Noguera-Troise, Ivan B. Lobov, Christopher Daly, John S. Rudge, Nicholas W. Gale, Stanley J. Wiegand, and George D. Yancopoulos ; Immune cells and inflammatory mediators as regulators of tumor angiogenesis / Michele De Palma and Lisa M. Coussens ; Contribution of endothelial progenitor cells to the angiogenic process / Marco Seandel, Andrea T. Hooper, and Shahin Rafii ; Tumor angiogenesis and the cancer stem cell model / Chris Folkins and Robert S. Kerbel ; Targeting the tumor microenvironment (stroma) for treatment of metastasis / Isaiah J. Fidler, Cheryl Hunt Baker, Kenji Yokoi, Toshio Kuwai, Toru Nakamura, Monique Nilsson, J. Erik Busby, Robert R. Langley, and Sun-Jin Kim |
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Section IV. Functional assessments of angiogenesis. Normalization of tumor vasculature and microenvironment / Rakesh K. Jain, Dan G. Duda, Tracy T. Batchelor, A. Gregory Sorensen, and Christopher G. Willett ; Targeted drug delivery to the tumor neovasculature / Grietje Molema ; Models for angiogenesis / Robert Auerbach ; Surrogates for clinical development / Sylvia S.W. Ng and Kim N. Chi ; Imaging of angiogenesis / Tristan Barrett and Peter L. Choyke ; Tumor endothelial markers / Janine Stevens and Brad St. Croix -- Section V. Clinical translation of angiogenesis inhibitors. Overview and clinical applications of VEGF-A / Napoleone Ferrara ; Protein tyrosine kinase inhibitors as antiangiogenic agents / Alexander Levitzki ; Therapeutic strategies that target the HIF system / Kristina M. Cook and Christopher J. Schofield ; The clinical utility of Bevacizumab / Jeanny B. Aragon-Ching, Ravi A. Madan, and James L. Gulley ; Development of Thalidomide and its IMiD derivatives / Cindy H. Chau, William Dahut, and William D. Figg ; TNP-470 : the resurrection of the first synthetic angiogenesis inhibitor / Hagit Mann-Steinberg and Ronit Satchi-Fainaro ; Clinical development of VEGF trap / John S. Rudge, Ella Ioffe, Jingtai Cao, Nick Papadopoulos, Gavin Thurston, Stanley J. Wiegand, and George D. Yancopoulos ; Recent advances in angiogenesis drug development / Cindy H. Chau and William D. Figg ; Combination of antiangiogenic therapy with other anticancer therapies / Beverly A. Teicher ; Immunotherapy of angiogenesis with DNA vaccines / Chien-Fu Hung, Archana Monie, and T.-C. Wu ; Challenges of antiangiogenic therapy of tumors / Roberta Sarmiento, Raffaele Longo, and Giampietro Gasparini ; Pharmacogenetics of antiangiogenic therapy / Guido Bocci, Giuseppe Pasqualetti, Antonello Di Paolo, Mario Del Tacca, and Romano Danesi -- Section VI. Angiogenesis in health & disease. Angiogenesis in the central nervous system / Carmen Ruiz de Almodovar, Serena Zacchigna, and Peter Carmeliet ; Lymphatic vascular system and lymphangiogenesis / Leah N. Cueni and Michael Detmar ; Ocular neovascularization / Peter A. Campochiaro ; Angiogenesis and pathology in the oral cavity / Luisa A. DiPietro ; Revascularization of wounds : the oxygen-hypoxia paradox / Thomas K. Hunt, Michael Gimbel, and Chandan K. Sen ; Journeys in coronary angiogenesis / Julie M.D. Paye, Chohreh Partovian, and Michael Simons ; Perspectives on the future of angiogenesis research / Douglas Hanahan |
| Summary |
A comprehensive, concise summary of tumor angiogenesis. This book is a reference for the angiogenesis field as it relates to oncology |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer eBooks |
| Subject |
Neovascularization.
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Neovascularization, Physiologic
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Neovascularization, Pathologic
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medicines (material)
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MEDICAL -- Physiology.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Neovascularization, Pathologic.
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Neovascularization.
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Neovascularization, Physiologic.
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Neovascularization
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| Form |
Electronic book
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| Author |
Figg, William D.
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Folkman, M. Judah.
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| LC no. |
2007934647 |
| ISBN |
9780387715186 |
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0387715185 |
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9780387715179 |
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0387715177 |
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