Limit search to available items
Book Cover
Author Symposium on Enzyme Defects and Immune Dysfunction (1978 : London, England)

Title Enzyme Defects and Immune Dysfunction
Published Amsterdam ; New York : Excerpta Medica, 1979


Description 1 online resource (301 pages)
Series Ciba Foundation symposium ; 68 (new ser.)
Novartis Foundation Symposia ; v. 909
Ciba Foundation symposium ; new ser. 68.
Novartis Foundation Symposia
Contents Enzyme Defects and Immune Dysfunction; Contents; Chairman's introduction; Adenosine deaminase and purine nucleoside phosphorylase deficiency: how they were discovered and what they may mean; Discussion; Buridan's ass: one man's view of the immune system; Discussion; Clinical delineation of adenosine deaminase deficiency; Discussion; Immunological aberrations in purine nucleoside phosphorylase deficiencies; Discussion; Immunodeficiency due to transcobalamin II deficiency; Discussion; General Discussion I Model systems for study of enzyme deficiencies
Nucleotide metabolism in cultured T cells and in cells of patients deficient in adenosine deaminase and purine nucleoside phosphorylaseDiscussion; Deoxyribonucleoside toxicity in adenosine deaminase and purine nucleoside phosphorylase deficiency: implications for the development of new immunosuppressive agents; Discussion; Ecto 5'-nucleotidase deficiency in primary hypogammaglobulinaemia; Discussion; General Discussion II The methylation hypothesis of adenosine toxicity; Enzymology of immunodeficiency states; Allosteric regulation of calf thymus ribonucleotide reductase; Discussion
Adenosine deaminase: characteristics of the normal and mutant forms of the human enzymeDiscussion; Purine nucleoside phosphorylase: the normal enzyme and structural alterations in immunodeficiency disease; Discussion; Purine nucleoside phosphorylase : immunodetection and characterization of the human enzyme; Enzyme replacement and other biochemical approaches to the therapy of adenosine deaminase deficiency; Discussion; An approach to the restoration of T cell function in a purine nucleoside phosphorylase deficient patient; Discussion; Purine metabolism in adenosine deaminase deficiency
Final General Discussion Selective treatment of lymphoid malignancy with adenosine deaminase inhibitorsDefects in differentiation underlying ADA and PNP deficiency; Search for new enzyme deficiencies; Index of contributors; Subject index
Bibliography Includes bibliographical references and indexes
Notes Print version record
Subject Immunological deficiency syndromes -- Congresses
Adenosine deaminase -- Congresses
Purines -- Metabolism -- Congresses
Enzymes -- Congresses
MEDICAL -- Endocrinology & Metabolism.
MEDICAL -- Nutrition.
Adenosine deaminase.
Immunological deficiency syndromes.
Purines -- Metabolism.
Genre/Form Conference papers and proceedings.
Form Electronic book
ISBN 9780470718193