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Title DNA repair and cancer : from bench to clinic / editors, Srinivasan Madhusudan, David M. Wilson III
Published Boca Raton : Taylor & Francis, 2013
Online access available from:
ProQuest Ebook Central Subscription    View Resource Record  


Description 1 online resource (xvii, 688 pages) : illustrations (some color)
Contents Overview of DNA repair pathways / Deborah L. Croteau and Vilhelm A. Bohr -- Longevity assurance by genome maintenance / Paul Hasty, Yousin Suh and Jan Vijg -- Genetic instability of cancer : biological predictions and clinical implications / Robert A. Beckman -- Radiation induced DNA damage, repair, and therapeutics / Lynn Harrison -- Chemotherapeutic alkylating agents in cancer treatment / Tracey D. Bradshaw -- O6-methylguanine-DNA methyltransferase (MGMT) in cancer protection and therapy / Bernd Kaina and Markus Christmann -- DNA mismatch repair : it's role in human carcinogenesis and as a predictive and/or prognostic biomarker for cancer therapy / Timothy J. Kinsella -- DNA base excision repair therapeutics : summary of targets with a focus on APE1 / Melissa L. Fishel, Carlo Vascotto and Mark R. Kelley -- Nucleotide excision repair : DNA repair capacity variability and cancer susceptibility / Li-E Wang and Qingyi Wei -- Fanconi anemia, interstrand cross-link repair, and cancer / Taraswi Banerjee, Sanjay Kumar Bharti and Robert M. Brosh, Jr -- Functions of translesion DNA polymerases : implications for cancer risk and opportunities as therapeutic targets / Kinrin Yamanaka and R. Stephen Lloyd -- P53 in DNA damage, repair and cancer therapeutics / Aditi Gurkar, Kiki Chu and Sam W. Lee -- ATM/ATR cell cycle checkpoints : mechanisms and manipulation in cancer therapy / Marie Fernet, Sara Chiker and Janet Hall -- The BRCA1-BRCA2 pathway of homologous recombination and the opportunity for synthetic lethal approaches to cancer therapy / Laura J. Eccles [and others] -- PARP and PARP inhibitor therapeutics / Nicola J. Curtin -- Tumor genetics and personalized medicine / Mary Ellen Urick and Daphne W. Bell -- The tumor microenvironment and DNA repair : implications for cancer progression and treatment / Norman Chan, Shaqil Kassam and Robert G. Bristow -- Early phase clinical trials using DNA repair inhibitors : lessons learnt / Miranda Payne and Mark Middleton
Summary DNA Repair is a rapidly advancing field in biology. Dr. Madhusudan and Dr. Wilson have brought together renowned experts to produce this exciting volume focused on DNA Repair and its relationship to cancer. DNA repair systems represent a major defense mechanism against DNA damaging environmental and intracellular damaging agents, such as sunlight, ionizing radiation and reactive oxygen species. Defects in DNA repair may predispose to cancer and likely influence the aging process. Since many approaches to eradicate cancer involve direct DNA-damaging agents, such as ionizing radiation and a battery of chemotherapeutics, strategic targeting of DNA repair mechanisms in cancer cells has emerged as an attractive approach to improve the efficacy of current treatment paradigms. The book provides a comprehensive overview of biochemical, preclinical and clinical aspects of the six major DNA Repair pathways operating in Man. In eighteen chapters, internationally recognized research scientists and clinical investigators review in detail (i) the molecular mechanisms of the various DNA repair systems, as well as the complementary cell cycle control components that prevent unmonitored cell growth, (ii) the role of DNA repair and DNA damage responses in cancer susceptibility and their relationship to aging, (iii) commonly used strategies to eliminate cancer cells, namely the employment of DNA-damaging agents, (iv) the concept of targeting DNA repair systems either through inhibition or the phenomenon of "synthetic lethality" to selectively kill cancer cells, (v) progress towards individualized medicine in the treatment of cancer, and (vi) the current picture of clinical efforts that engage DNA repair targeting strategies. 'DNA Repair and Cancer: From Bench to Clinic' will provide essential information to scientists, pharmaceutical investigators and clinicians interested in cancer therapy
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Neoplasms -- genetics.
DNA Damage -- drug effects.
DNA Damage -- physiology.
DNA Repair -- drug effects.
DNA Repair -- physiology.
Neoplasms -- drug therapy.
DNA damage -- Effect of drugs on
DNA damage -- Physiology
DNA repair -- Physiology
Tumors -- Genetics
DNA damage.
DNA repair.
HEALTH & FITNESS -- Diseases -- Cancer.
MEDICAL -- Oncology.
Form Electronic book
Author Madhusudan, Srinivasan.
Wilson, David M., III, 1967-
ISBN 1466577444