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Title Amyloid and related disorders : surgical pathology and clinical correlations / Maria M. Picken, Ahmet Dogan, Guillermo A. Herrera, editors
Edition Second edition
Published [New York] : Humana Press, [2015]


Description 1 online resource
Series Current clinical pathology
Current clinical pathology.
Contents Dedication; Preface (Second Edition); Acknowledgments; Contents; Contributors; Part I: Introduction/General; 1: Aspects of the History and Nomenclature of Amyloid and Amyloidosis; A Short History of Amyloid; Biochemical Nature of Amyloid; Diagnosis of Amyloidosis; Nomenclature; What Is Amyloid?; Older Nomenclatures; Modern Amyloid Nomenclature; References; 2: Amyloid Diseases at the Molecular Level: General Overview and Focus on AL Amyloidosis; General Overview; What Makes a Protein Amyloidogenic?; Common Constituents of Amyloid Deposits; Amyloid Structure
Amyloid Formation: From Monomers to Fibrils Kinetics of Fibril Formation; Organ Tropism; Mechanisms of Tissue Damage; Immunoglobulin Light Chain Amyloidosis (AL); The Amyloidogenic Clone; Genetics of Amyloidogenic Light Chains; Structural Features of Amyloidogenic Light Chains; Mechanisms of Toxicity; Organ Tropism in AL Amyloidosis; Clinical Manifestations; Clinical Approach; References; 3: AA Amyloidosis; AA Amyloidosis in Rheumatic Disease; The Hereditary Autoinflammatory Diseases; Monogenic Autoinflammatory Diseases; Familial Mediterranean Fever
Tumor Necrosis Factor Receptor- Associated Periodic Syndrome Cryopyrin-Associated Periodic Fever Syndromes; Hyper IgD Syndrome; Other Monogenic Autoinflammatory Diseases; Polygenic and Complex Autoinflammatory Disease; Inflammatory Bowel Disease; Sarcoidosis and Sinus Histiocytosis with Massive Lymphadenopathy; AA Amyloidosis and Obesity; Summary; References; 4: Leukocyte Cell-Derived Chemotaxin 2 Amyloidosis (ALECT2); Introduction; Overview of LECT2 Biology and ALECT2 Pathogenesis; Renal ALECT2 Amyloidosis; Hepatic ALECT2 Amyloidosis; Conclusions; References
Radiological ImagingPlain X-Rays; Scintigraphy; Ultrasonography; X-Ray Computed Tomography; Magnetic Resonance Imaging; Tissue Biopsy; Treatment; Supportive Treatment; Specific Treatment; Prevention; Dialysis Modality; Ultrapure Dialysate; Conclusion; References; 7: Localized Amyloidoses and Amyloidoses Associated with Aging Outside the Central Nervous System; Introduction; Localized AL Amyloidosis; Amyloid in Endocrine Organs and Tumors; Islet of Langerhans; Parathyroid Glands; Amyloid in the Cardiac Atria; Pituitary Gland; Amyloid in Endocrine Tumors
Summary The second edition of this text presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue, skin, lymph node/spleen and bone marrow pathology is also covered. Amyloid and Related Disorders, Second Edition will be invaluable to specialized and general pathologists as well as cytopathologists. Other medical professionals may also benefit from this concise update on the systemic amyloidoses
Analysis pathologie
public health
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed August 20, 2015)
Subject Amyloidosis.
Amyloidosis -- diagnosis
Amyloidosis -- pathology
Amyloid -- adverse effects
Amyloidosis -- therapy
Renal medicine & nephrology.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Form Electronic book
Author Picken, Maria M., editor.
Herrera, Guillermo A., MD, editor.
Doğan, Ahmet, editor.
ISBN 9783319192949