Title Role of nutraceuticals in cancer chemosensitization / Alok Chandra Bharti, Bharat Bhushan Aggarwal

Edition First edition Published London, United Kingdom : Academic Press, [2018] ©2018

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Description 1 online resource Series Cancer sensitizing agents for chemotherapy ; volume 2 Cancer sensitizing agents for chemotherapy ; v. 2. Contents Front Cover -- Cancer Sensitizing Agents for Chemotherapy: Role of Nutraceuticals in Cancer Chemosensitization -- Copyright -- Contents -- Contributors -- About the Editors -- About the Series Editor -- Aims and Scope for Series â#x80;Cancer Sensitizing Agents for Chemotherapyâ#x80;#x9D; -- Preface -- Chapter 1: Pathways Linked to Cancer Chemoresistance and Their Targeting by Nutraceuticals -- Introduction -- Chemotherapy -- Alkylating Agents -- Cell Cycle Inhibitors/Antimicrotubule Agents -- Antimetabolites -- Antibiotics -- Topoisomerase Inhibitors Targeted TherapyTarget-Specific Antibodies -- Small Molecule Inhibitors -- Chemoresistance: Problem in Curing Cancer -- Mechanism of Chemoresistance -- Drug Transporters -- Enhanced DNA Repair System -- Drug Inactivation -- Altered Drug Targets -- Epithelial-Mesenchymal Transition -- Inhibition of Apoptosis -- Autophagy -- Aberrant Expression and Constitutive Activation of Transcription Factors -- Nuclear Factor-Kappa B (NF-ÎðB) -- Signal Transducers and Activators of Transcription 3 (STAT-3) -- Activating Protein-1 (AP-1) Activation of Self-Renewal PathwaysChemosensitization: An Approach to Target Cancer -- Nutraceuticals as Chemosensitizers: Opportunities and Challenges -- Conclusion -- Conflict of Interest -- Acknowledgments -- References -- Chapter 2: The Potential of Curcumin: A Multitargeting Agent in Cancer Cell Chemosensitization -- Introduction -- Molecular Targets of Curcumin -- Chemosensitization Studies of Curcumin in Different Cancers -- Curcumin Mediated Chemosensitization in Bladder Cancer -- Curcumin Mediated Chemosensitization in Brain Cancer Curcumin Mediated Chemosensitization in Breast CancerCurcumin Mediated Chemosensitization in Cervical Cancer -- Curcumin Mediated Chemosensitization in Colon Cancer -- Curcumin Mediated Chemosensitization in Esophageal Cancer -- Curcumin Mediated Chemosensitization in Leukemia -- Curcumin Mediated Chemosensitization in Lung Cancer -- Curcumin Mediated Chemosensitization in Multiple Myeloma -- Curcumin Mediated Chemosensitization in Ovarian Cancer -- Curcumin Mediated Chemosensitization in Pancreatic Cancer -- Curcumin Mediated Chemosensitization in Prostate Cancer Curcumin Mediated Chemosensitization in Other CancersHybrid Curcumin -- Conclusion -- Conflict of Interest -- Acknowledgment -- References -- Further Reading -- Chapter 3: Role of Resveratrol in Chemosensitization of Cancer -- Introduction -- Source and Chemistry of Resveratrol -- Possible Molecular Mechanisms of Chemoresistance in Cancer -- ATP-Dependent Drug Efflux -- Drug Detoxification -- Alterations in Drug Target Molecules -- Alterations in DNA Damage Repair Pathways -- Regulation of Cell Cycle Arrest -- Regulation of Apoptosis Summary Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy Notes Includes index Bibliography Includes bibliographical references and index Notes Vendor-supplied metadata Subject Cancer -- Diet therapy. Functional foods. Cancer -- Chemotherapy. Neoplasms -- drug therapy Neoplasms -- metabolism Micronutrients -- therapeutic use Micronutrients -- metabolism Dietary Supplements -- analysis Drug Resistance, Neoplasm -- drug effects HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Cancer -- Chemotherapy Cancer -- Diet therapy Functional foods Form Electronic book Author Aggarwal, Bharat B., 1950- author. ISBN 9780128123744 0128123745 9780128164723 0128164727 0128123737 9780128123737

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