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Book Cover
Author Boraschi, D. (Diana), author

Title Immune rebalancing : the future of immunosuppression / Diana Boraschi, Giselle Penton-Rol
Published London Wall [UK] : Academic Press is an imprint of Elsevier, 2016


Description 1 online resource
Contents Front Cover; Immune Rebalancing; Copyright Page; Contents; List of Contributors; 1 Pharmacological Strategies Using Biologics as Immunomodulatory Agents; 1.1 Introduction; 1.2 From Nonspecific to Targeted Immunosuppression; 1.3 From Immunosuppression to Immune Rebalancing; 1.4 Conclusions; Acknowledgments; References; I. Mechanisms of Immune-Related Pathologies and their Current Treatment; 2 Advance in Therapies for Rheumatoid Arthritis: New Perspectives; 2.1 Introduction; 2.2 Rheumatoid Arthritis Management; 2.2.1 Glucococorticoids; 2.2.2 Methotrexate; 2.2.3 Leflunomide; 2.2.4 Sulfasalazine
2.2.5 Cyclosporin A2.2.6 Azathioprine; 2.2.7 Cyclophosphamide; 2.2.8 Antimalarials; 2.2.9 Biologics; 2.2.10 Tumor Necrosis Factor Inhibitors; 2.2.11 T-Lymphocyte Costimulation Blocker: Abatacept; 2.2.12 Anti-B-Cell Therapy: Rituximab; 2.2.13 Anakinra; 2.2.14 Tocilizumab; 2.2.15 Protein Kinase Inhibitors; 2.3 New Alternatives for the Treatment of RA; 2.4 Loss of Immune Tolerance as a Factor for RA Development: A Possible Target; 2.5 Resolution of Inflammation; 2.5.1 Lipid Mediators; 2.5.2 Annexin A1; 2.6 Challenges; 2.7 Concluding Remarks; References
Summary Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposesEncourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infectionsExamines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approachesProvides information on the new strategies for drug development in this fieldConsiders the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader's strategy for addressing therapeutic immune modulations
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed February 17, 2016)
Subject Immunopharmacology.
Immunological tolerance.
Immunosuppression Therapy
Immune Tolerance
MEDICAL -- Pharmacology.
Immunological tolerance.
Form Electronic book
Author Penton-Rol, Giselle, author
ISBN 9780128033364