Title Biotransformation and metabolite elucidation of xenobiotics / edited by Ala F. Nassar

Published Hoboken, N.J. : John Wiley & Sons, ©2010

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Description 1 online resource (xi, 328 pages) Contents Frontmatter -- Human Biotransformation / Andrew Parkinson, Brian W Ogilvie, Brandy L Paris, Tiffini N Hensley, Greg J Loewen -- Analytical Tools and Approaches for Metabolite Identification in Drug Metabolism / Yongmei Li -- Tools of Choice for Accelerating Metabolite Identification: Mass Spectrometry Technology Drives Metabolite Identification Studies Forward / Ala F Nassar -- Improving Drug Design: Considerations for the Structural Modification Process / Ala F Nassar -- Case Study: The Unanticipated Loss of N from Novel DNA Alkylating Agent Laromustine by Collision-Induced Dissociation: Novel Rearrangements / Ala F Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, Tukiet T Lam -- Case Study: Identification of Metabolite/Decomposition Products of the Novel DNA Alkylating Agent Laromustine / Ala F Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, Tukiet T Lam -- Strategies for the Detection of Reactive Intermediates in Drug Discovery and Development / Mark P Grillo -- Safety Testing of Drug Metabolites: Mist Guidance Impact on the Practice of Industrial Drug Metabolism / J Greg Slatter -- Index Human biotransformation / Andrew Parkinson -- Analytical tools and approaches for metabolite identification in drug metabolism / Yongmei Li -- Tools of choice for accelerating metabolite identification : mass spec technology drives metabolite identification studies forward / Ala Nassar -- Improving drug design : considerations for the structural modification process / Ala Nassar -- Case study : the unanticipated loss of N2 from novel dna alkylating agent laromustine by collision-induced dissociation : novel rearrangements / Ala Nassar, Tukiet T. Lam -- Case study : identification of in vitro metabolite/decomposition products of the novel DNA alkylating agent laromustine / Ala Nassar, TuKiet T. Lam -- Strategies for the detection of reactive intermediates in drug discovery and development / Mark P. Grillo -- Safety testing of drug metabolites : MIST guidance impact on the practice of industrial drug metabolism / J. Greg Slatter Summary The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools Bibliography Includes bibliographical references and index Notes English Print version record Subject Xenobiotics -- Metabolism Metabolites -- Identification Biotransformation (Metabolism) Metabolites -- Identification Xenobiotics -- metabolism Xenobiotics -- pharmacology Biotransformation -- physiology Drug Discovery Biotransformation MEDICAL -- Toxicology. Biotransformation (Metabolism) Metabolites Xenobiotics -- Metabolism Genre/Form Field guides Form Electronic book Author Nassar, Ala F. LC no. 2010016629 ISBN 9780470890387 047089038X 9780470890370 0470890371 1118097777 9781118097779 1282782894 9781282782891 9786612782893 6612782897

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