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Title Non-neuronal mechanisms of brain damage and repair after stroke / Jun Chen, John H. Zhang, Xiaoming Hu, editors
Published Switzerland : Springer, 2016


Description 1 online resource (xiii, 408 pages) : illustrations
Series Springer series in translational stroke research
Springer series in translational stroke research.
Contents Introduction: Nonneuronal Mechanisms and Targets for Stroke; Contents; Contributors; Part I: Microvascular Integrity in Stroke; Structural Alterations to the Endothelial Tight Junction Complex During Stroke; 1 Introduction; 2 Normal BBB Structure and Function.; 3 Alterations in BBB Function After Stroke; 4 Alterations to TJ Structure After Stroke; 5 Signaling Mechanisms Underlying Alterations in TJ Structure in Stroke; 6 Non-TJ Pathways Involved in BBB Hyperpermeability After Stroke; 7 Therapeutic Interventions; 8 Conclusions; References; Role of Pericytes in Neurovascular Unit and Stroke
1 Neurovascular Unit and Stroke2 Pericytes; 2.1 Regulation of Microcirculatory Blood Flow and BBB by Pericytes; 2.2 Pericytes Are Vulnerable to Ischemic Injury; 3 Changes in Pial and Penetrating Arteries Shortly After Stroke; 4 Incomplete Microcirculatory Reflow After Recanalization; 5 Clinical Evidence for "No-Reflow" After Recanalization Therapies for Stroke; 6 Role of Pericytes in CADASIL; 7 Post-stroke Angioneurogenesis and Pericytes; References; Glial Support of Blood-Brain Barrier Integrity: Molecular Targets for Novel Therapeutic Strategies in Stroke; 1 Introduction
2 The Neurovascular Unit2.1 Components of the Neurovascular Unit; 2.1.1 Endothelial Cells and the Blood-Brain Barrier; 2.2 Molecular Characteristics of the BBB; 2.2.1 Tight Junction Protein Complexes; 2.2.2 Adherens Junctions; 2.3 Transporters; 2.4 Astrocytes; 2.5 Microglia; 2.6 Pericytes; 2.7 Neurons; 2.8 Extracellular Matrix; 3 Ischemic Stroke; 3.1 Overview of Ischemic Stroke; 3.2 The Neurovascular Unit in Ischemic Stroke; 3.2.1 Disruption of the Blood-Brain Barrier; 3.3 Ischemic Stroke and Glial Support of the BBB; 3.4 Targeting the Neurovascular Unit in Ischemic Stroke
3.4.1 Targeting the Tight Junction3.5 Targeting Endogenous BBB Transporters; 3.6 Targeting Glial Support of the BBB; 4 Conclusion; References; Barrier Mechanisms in Neonatal Stroke; 1 Introduction; 2 Development of the BBB and Other Brain Barriers; 3 Blood-Brain Barrier and Adult Stroke; 4 Maturation-Dependent Susceptibility of the BBB to Inflammation; 5 Models of Neonatal Focal Stroke and Hypoxia-Ischemia; 6 BBB Integrity After Neonatal Focal Stroke and Hypoxia-Ischemia; 7 Leukocyte and BBB Integrity After Neonatal Stroke; 8 BBB Integrity, Angiogenesis and Brain Repair After Neonatal Stroke
9 Conclusions and Future DirectionsReferences; Angiogenesis: A Realistic Therapy for Ischemic Stroke; 1 Introduction; 2 Overview of Angiogenesis; 3 Angiogenesis After Ischemic Stroke; 4 Regulation of Angiogenesis After Ischemic Stroke; 5 Functional Roles of Angiogenesis in Stroke Long-Term Remodeling and Functional Recovery; 6 Therapeutic Angiogenesis in Ischemic Stroke; References; Part II: Glial Cells in Stroke; Astrocytes as a Target for Ischemic Stroke; 1 A Brief Overview of Astrocytes; 2 Astrocytes in Ischemic Stroke; 2.1 Astrocyte and Glutamate Uptake in Ischemic Stroke
Summary This book provides a comprehensive overview of the latest research in the role of non-neuronal cells - astrocytes, oligodendrocytes, endothelial cells, pericytes, microglia, and other immune cells in ischemic brain injury and long-term recovery. In these cases, neurodegeneration and brain repair are controlled in a sophisticated system, incorporating interactions between different cell types and cellular systems. Also explored are the therapeutic strategies that target non-neuronal responses after stroke and their translational potentials
Notes Online resource; title from PDF title page (SpringerLink, viewed August 23, 2016)
Subject Cerebrovascular disease -- Molecular aspects
Brain damage -- Molecular aspects
Cerebral ischemia.
Brain Ischemia
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Cerebral ischemia.
Genre/Form Electronic books
Form Electronic book
Author Chen, Jun, editor
Zhang, J. H. (John H.), editor.
Hu, Xiaoming, editor
ISBN 9783319323374