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Book Cover
E-book

Title Anti-inflammatory drug discovery / edited by Jeremy I. Levin, Stefan Laufer
Published Cambridge, U.K. : Royal Society of Chemistry, ©2012

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Description 1 online resource (xv, 528 pages) : illustrations (some color)
Series RSC drug discovery series, 2041-3203 ; 26
RSC drug discovery series ; 26. 2041-3203
Contents Section 1. Arachidonic acid cascade -- section 2. Kinases -- section 3. GPCRs -- section 4. Sphingolipids -- section 5. Steroid hormone receptors
Summary Anti-Inflammatory Drug Discovery provides a comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and provides a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory mechanisms of action. The editors, with extensive experience in this field, have selected key thought-leaders who will bring their experience to the medicinal chemistry literature for each target, ranging from components of the arachadonic acid cascade, to kinases, GPCRs, sphingolipids and others, to summarize its background biology and detail new insights, major advances and issues related to bringing new anti-inflammatory therapies to market. Consisting of five main sections key targets covered will include the AA Cascade: mPGES1, cPLA2, Leukotriene A4 Hydrolase, CRTH2; Kinases: P38/PDE4, MAPKAP Kinase 2 (MK2), Syk Kinase Inhibitors, Jak Kinases, IKK, Bruton's Tyrosine Kinase; GPCRs: CCR1, CCR2 Antagonists, CB2 Agonists; Sphingolipids: S1P1 Receptor Agonists, Sphingosine Lyase and Sphingosine Kinase 1 and a final miscellaneous section that looks at Non-Steroidal Dissociated Glucocorticoid Receptor Agonists. The book will be essential reading for pharmacologists, medicinal chemists and pharmaceutical scientists working in industry and academia."-- Provided by publisher
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Anti-inflammatory agents -- Research
Anti-inflammatory agents -- Therapeutic use -- Technological innovations
Inflammation -- Treatment -- Research
Pharmaceutical chemistry.
Pharmacology.
Chemistry.
Life sciences.
Physical sciences.
Anti-inflammatory agents.
Investigative Techniques
Chemistry, Pharmaceutical
Therapeutic Uses
Analytical, Diagnostic and Therapeutic Techniques and Equipment
Pharmacology
Pharmacologic Actions
Chemistry
Biological Science Disciplines
Chemical Actions and Uses
Natural Science Disciplines
Chemicals and Drugs
Disciplines and Occupations
Drug Discovery
Anti-Inflammatory Agents
pharmacology.
chemistry.
biological sciences.
physical sciences.
Chemistry.
Biochemistry.
MEDICAL -- Pharmacology.
Anti-inflammatory agents.
Chemistry.
Life sciences.
Pharmaceutical chemistry.
Pharmacology.
Physical sciences.
Genre/Form Electronic books
Form Electronic book
Author Levin, Jeremy Ian, 1956-
Laufer, Stefan.
ISBN 9781849735346
1849735344