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Title Tuberculosis : a comprehensive clinical reference / [edited by] H. Simon Schaaf, Alimuddin I. Zumla ; co-editors, John M. Grange [and others]
Published [Edinburgh] : Saunders/Elsevier, 2009


Description 1 online resource (xxvi, 1014 pages, 8 unnumbered pages of plates) : illustrations (some color), maps, portraits
Contents Front Cover; Tuberculosis: A Comprehensive Clinical Reference; Copyright Page; Contents; Foreword; Preface; Contributors; Dedication; Acknowledgements; Abbrevations; Section 1: History and Epidemiology of Tuberculosis; Chapter 1: The history of tuberculosis: Past, present, and challenges for the future; Conquests and Empires; EBB Tide; Discovery of the Cause; Diagnosis; The Search for a Cure; Challenges; Chapter 2: Transmission of Mycobacterium tuberculosis; Introduction and Historical Perspective; Epidemiological Data on the Determinants of Tuberculosis Transmission
Mycobacterial Factors, Strain Differences, and Interactions with Source, Environment, and HostHuman Host Factors which Affect Vulnerability to Tuberculosis Infection; Mathematical Modelling of M. Tuberculosis Transmission; Future Prospects and Other Important Considerations in Infection Control; Chapter 3: The global epidemiology of tuberculosis; Natural History of Tuberculosis; Conclusions; References; Chapter 4: Molecular methods and their application in tuberculosis epidemiology; Introduction; Current Genotyping Methods Used in Epidemiological Studies of Tuberculosis
The Interpretation of Molecular Epidemiology DataThe Application of Molecular Epidemiology to Tuberculosis; Summary; References; Chapter 5: Epidemiology of childhood tuberculosis; Introduction; Definitions; Transition Framework; Sources of Information; Global Estimates of Burden of Disease in Children; Epidemiology of Transitions; The Way Forward; References; Section 2: Basic Science; Chapter 6: The genus Mycobacterium and the Mycobacterium tuberculosis complex; The Mycobacteria and the Tubercle Bacillus -- An Historical Introduction; Classification of the Genus Mycobacterium
The Ecology of MycobacteriaGrowth Characteristics and Metabolism of Mycobacteria; Antigenic Structure of Mycobacteria; Macromolecular Structure of Mycobacteria; Definition of the M. Tuberculosis Complex; The Genome of M. Tuberculosis and Other Mycobacteria; Culture; Treatment; Mycobacteriophages, Lysogeny, and Phage Typing; Plasmids or Episomes; The Evolution and Devolution of the M. Tuberculosis Complex; Determinants of Virulence and Pathogenicity; Chapter 7: Other mycobacteria causing human disease; Introduction; Epidemiology and Risk Factors; Bacteriology
Migrants and Tuberculosis Disease in High-Burden CountriesTransmission and Pathogenesis; Clinical Presentation and Diagnosis; Prevention of NTM Infections; References; References; Chapter 8: The basic immunology of tuberculosis; Introduction; Protective Immunity; Dendritic Cells; The Role of Toll-Like Receptors; Phagosomal Maturation and Antigen Processing; Discussion; Macrophage and Dendritic Cell Cytokine Production; The Activation of T-Lymphocytes; T-Lymphocyte and NK Cell Functions; Interferon-gamma; Chemokines, Adhesion Molecules and Cellular Migration; Microbial Elimination
Summary This book provides all the vital information you need to know about tuberculosis, especially in the face of drug-resistant strains of the disease. Coverage includes which patient populations face an elevated risk of infection, as well as which therapies are appropriate and how to correctly monitor ongoing treatment so that patients are cured. Properly administer screening tests, interpret their results, and identify manifestations of the disease, with authoritative guidance from expert clinicians from around the world. Discusses screening tests for tuberculosis so you can interpret their results and identify not only common manifestations of the disease, but also those that are comparatively rare, such as tuberculosis in pregnant women. Covers all clinical aspects of tuberculosis in children, including current practices on managing those infected with HIV. Provides details on how best to interact with the public health system in both industrialized and developing countries. Addresses the social aspects of tuberculosis and presents the latest advances on new and potential vaccines against tuberculosis. Offers the expertise of internationally recognized tuberculosis clinicians to provide you with well-rounded, global coverage. Features numerous illustrations to provide clear and detailed depictions of rare manifestations of tuberculosis
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Tuberculosis.
Tuberculosis -- Epidemiology
Tuberculosis -- Pathophysiology
Tuberculosis -- Treatment
MEDICAL -- Oncology.
Tuberculosis -- Epidemiology
Tuberculosis -- Treatment
Form Electronic book
Author Schaaf, H. Simon
Zumla, Alimuddin
Grange, John M
ISBN 9781416039884