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Title Treatment and prevention of malaria : antimalarial drug chemistry, action and use / Henry M. Staines, Sanjeev Krishna, editors
Published Basel : Springer, ©2012


Description 1 online resource (x, 315 pages)
Series Milestones in drug therapy
Milestones in drug therapy.
Contents Antimalarial drugs and the control and elimination of malaria -- 4-Aminoquinolines: chloroquine, amodiaquine and next generation analogues -- Cinchona alkaloids: quinine and quinidine -- 8-Aminoquinolines: primaquine and tafenoquine -- Other 4-methanolquinolines, amyl alcohols and phentathrenes: mefloquine, lumefantrine, halofantrine, piperaquine and pyronaridine -- Antifolates: pyrimethamine, proguanil, sulphadoxine and dapsone -- Naphthoquinones: atovaquone, and other antimalarials targeting mitochondrial functions -- Non-antifolate antibiotics: clindamycin, doxycycline, azithromycin and fosmidomycin -- Artemisinins: artemisinin, dihydroartemisinin, artemether, arteether and artesunate -- Second generation peroxides: the OZs and artemisone -- Combination therapy in light of emerging artemisinin resistance -- New medicines to combat malaria: an overview of the global pipeline of therapeutics -- Molecular markers of Plasmodium resistance to antimalarials -- Prevention of malaria -- Malaria diagnostics: lighting the path
Summary Annotation Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail
Analysis Medicine
Drug interactions
Medical parasitology
Emerging infectious diseases
Infectious Diseases
Drug Resistance
Bibliography Includes bibliographical references and index
Notes English
Subject Antimalarials.
Malaria -- Chemotherapy.
Malaria -- Prevention.
Antimalarials -- pharmacology
Antimalarials -- therapeutic use
Disease Eradication
Malaria -- prevention & control
HEALTH & FITNESS -- Diseases -- Contagious.
MEDICAL -- Infectious Diseases.
Malaria -- Chemotherapy
Malaria -- Prevention
Form Electronic book
Author Staines, Henry M
Krishna, S. (Sanjeev)
ISBN 9783034604802