| Description |
1 online resource (xvii, 411 pages) : illustrations (some color) |
| Contents |
Cover -- Click Chemistry for Biotechnology13;and Materials Science -- Contents -- Preface -- List of Contributors -- Acknowledgments -- 1 Click Chemistry: A Universal Ligation Strategy for Biotechnology and Materials Science -- 1.1 Introduction -- 1.2 Selected Examples of Click Reactions in Materials Science and Biotechnology -- 1.3 Potential Limitations of Click Chemistry -- 1.4 Conclusions -- References -- 2 Common Synthons for Click Chemistry in Biotechnology -- 2.1 Introduction 8211; Click Chemistry -- 2.2 Peptides and Derivatives -- 2.3 Peptoids -- 2.4 Peptidic Dendrimers -- 2.5 Oligonucleotides -- 2.6 Carbohydrates -- 2.7 Conclusion -- References -- 3 Copper-free Click Chemistry -- 3.1 Introduction -- 3.2 Bio-orthogonal Ligations -- 3.3 Applications of Copper-free Click Chemistries -- 3.4 Summary and Outlook -- References -- 4 Protein and Peptide Conjugation to Polymers and Surfaces Using Oxime Chemistry -- 4.1 Introduction -- 4.2 Protein/Peptide8211;Polymer Conjugates -- 4.3 Immobilization of Proteins and Peptides on Surfaces -- 4.4 Conclusions -- References -- 5 The Role of Click Chemistry in Polymer Synthesis -- 5.1 Introduction -- 5.2 Polymerization via CuAAC -- 5.3 Post-polymerization Modification via Click Chemistry -- 5.4 Polymer8211;Biomacromolecule Conjugation -- 5.5 Functional Nanomaterials -- 5.6 Summary and Outlook -- References -- 6 Blocks, Stars and Combs: Complex Macromolecular Architecture Polymers via Click Chemistry -- 6.1 Introduction -- 6.2 Block Copolymers -- 6.3 Star Polymers -- 6.4 Graft Copolymers -- 6.5 Concluding Remarks -- References -- 7 Click Chemistry on Supramolecular Materials -- 7.1 Introduction -- 7.2 Click Reactions on Rotaxanes, Cyclodextrines and Macrocycles -- 7.3 Click Reactions on DNA -- 7.4 Click Reactions on Supramolecular Polymers -- 7.5 Click Reactions on Membranes -- 7.6 Click Reactions on Dendrimers -- 7.7 Click Reactions on Gels and Networks -- 7.8 Click Reactions on Self-assembled Monolayers -- References -- 8 Dendrimer Synthesis and Functionalization by Click Chemistry for Biomedical Applications -- 8.1 Introduction -- 8.2 Dendrimer Synthesis -- 8.3 Dendrimer Functionalization -- 8.4 Conclusions and Future Directions -- References -- 9 Reversible Diels8211;Alder Cycloaddition for the Design of Multifunctional Network Polymers -- 9.1 Introduction -- 9.2 Design of Polymer Networks -- 9.3 Application of Diels8211;Alder Linkages to Polymer Systems -- 9.4 Conclusions -- References -- 10 Click Chemistry in the Preparation of Biohybrid Materials -- 10.1 Introduction -- 10.2 Polymer-containing Biohybrid Materials -- 10.3 Biohybrid Structures based on Protein Conjugates -- 10.4 Biohybrid Amphiphiles -- 10.5 Glycoconjugates -- 10.6 Conclusions -- References -- 11 Functional Nanomaterials using the Cu-catalyzed Huisgen Cycloaddition Reaction -- 11.1 Introduction -- 11.2 Inorganic Nanoparticles -- 11.3 Carbon-based Nanomaterials -- 11.4 Self-assembled Organic Structures -- 11.5 Virus Particles -- 11.6 Conclusions -- References -- 12 Copper-catalyzed 8216;Click8217; Chemistry for Surface Engineering -- 12.1 Introduction -- 12.2 Synthesis of Alkyne or Azide-functionalized Surfaces -- 12.3 Spatially Controlled Click Chemistry -- 12.4 Copper-catalyzed Cli |
| Summary |
Mimicking natural biochemical processes, click chemistry is a modular approach to organic synthesis, joining together small chemical units quickly, efficiently and predictably. In contrast to complex traditional synthesis, click reactions offer high selectivity and yields, near-perfect reliability and exceptional tolerance towards a wide range of functional groups and reaction conditions. These 'spring loaded' reactions are achieved by using a high thermodynamic driving force, and are attracting tremendous attention throughout the chemical community. Originally introduced with the focus on dru |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Biotechnology.
|
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Combinatorial chemistry.
|
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Macromolecules -- Synthesis.
|
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Materials science.
|
| Form |
Electronic book
|
| ISBN |
0470748850 (electronic bk.) |
|
0470748869 (ebook) |
|
6612472065 |
|
9780470748855 (electronic bk.) |
|
9780470748862 (ebook) |
|
9786612472060 |
|
