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Title Cortical deficits in schizophrenia : from genes to function / edited by Patricion O'Donnell
Published New York : Springer, ©2008


Description 1 online resource (xii, 239 pages) : illustrations (some color)
Contents Schizophrenia genes: searching for common features, functions, and mechanisms -- Towards a molecular classification of illness: effects of schizophrenia susceptibility loci on clinical symptoms and cognitive function -- Homer: a genetic factor in schizophrenia? -- Neuroregulin-erbB signaling and the pathogenesis of schizophrenia -- Nicotinic cholinergic cortical dysfunction in schizophrenia -- Role for glutamate receptors, transporters, and interacting proteins in cortical dysfunction in schizophrenia -- Cortical circuit dysfunction in the NMDA receptor hypofunction model for the psychosis of schizophrenia -- Alterations in hippocampal function in schizophrenia: its genetic associations and systems implications -- Identifying novel target genes in psychotic disorder network association analyses -- Alterations in cortical GABA neurotransmission in schizophrenia: causes and consequences -- Increased cortical excitability as a critical element in schizophrenia pathophysiology
Summary "It is evident that although there are no genes that individually confer a strong liability, several candidate gene alleles do confer some risk, and perhaps a combination of genes could cause the emergence of symptoms in this multi-faceted psychiatric condition. As the research on predisposing genes soars, it is becoming clear that we need to be able to identify cellular processes the genes control and to provide patho-physiological scenarios that could link those cellular phenomena with symptoms. Cortical Deficits in Schizophrenia: From Genes to Function elaborates on that link." "Cortical Deficits in Schizophrenia: From Genes to Function will prove a useful tool for those interested in a better understanding of schizophrenia. Even if more predisposing genes (not included in this book) become identified, the work laid out here will prove critical for assigning a functional (or dysfunctional) role to those genes. Although this is a fast-evolving field, the information and concepts covered in this book will likely be useful for years to come."--Jacket
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer e-books
Subject Schizophrenia -- Genetic aspects.
Schizophrenia -- Pathophysiology
Cerebral cortex -- Pathophysiology
Schizophrenia -- genetics
Schizophrenia -- physiopathology
Cerebral Cortex -- physiopathology
PSYCHOLOGY -- Psychopathology -- Schizophrenia.
Schizophrenia -- Pathophysiology.
Cerebral cortex -- Pathophysiology.
Schizophrenia -- genetics.
Schizophrenia -- physiopathology.
Cerebral Cortex -- physiopathology.
Schizophrenia -- Genetic aspects.
Sciences de la vie.
Schizophrenia -- Genetic aspects
Schizophrenia -- Pathophysiology
Genetische Variabilität
Form Electronic book
Author O'Donnell, Patricio.
LC no. 2007933066
ISBN 9780387743516