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Title Selective estrogen receptor modulators : a new brand of multitarget drugs / Antonio Cano Sanchez, Joaquim Calaf i Alsina, José-Luis Dueñas-Díez (editors)
Published Berlin ; New York : Springer, ©2006


Description 1 online resource (xvii, 357 pages) : illustrations
Contents Part I : Basic area -- 1. Molecular mechanisms of estrogen action in target tissues / B. Nicolás Díaz Chico, Domingo Navarro Bosch, Juan C. Díaz Chico and Eduardo Escrich Escriche -- 2. Clinical pharmacology of Selective Estrogen Receptor Modulators (SERMs) / Fernando Marín and Ma Carmen Barbancho -- 3. Action of Selective Estrogen Receptor Modulators (SERMs) through the classical mechanism of estrogen action / Fernando Marín and Ma Barbancho -- 4. Cellular and molecular basis for acute nongenomically mediated actions of SERMs / Mario Díaz, Jorge Marrero-Alonso, Benito García Marrero, Raquel Marín and Tomás Gomez, et al. -- 5. The hypothalamus-pituitary-ovarian axis as a model system for the study of SERM effects : an overview of experimental and clinical studies / R. Alonso, F. Marín, M. González, P. Guelmes and C. Bellido, et al. -- 6. Pure antiestrogens / Carlos Hermenegildo -- Part II : Clinical area -- 7. Physiological regulation of bone metabolism and estrogen agonism / Miguel Angel García-Pérez -- 8. The role of SERMs in the treatment of osteoporosis / Adolfo Díez-Pérez and José Luis Dueñas-Díez -- 9. Cardiovascular disease and SERMs / Antonio Cano -- 10. SERMs and the breast / Joaquim Calaf i Alsina and Antonio Cano Sanchez -- 11. Endometrial effects of SERMs / Santiago Palacios -- 12. Benign gynecological diseases and SERMs / Stefano Palomba and Fulvio Zullo -- 13. Other clinical effects of SERMs / P. Acién, F. Quereda and M.I. Acién -- 14. The role of SERMs in the management of postmenopausal women / Joaquim Calaf i Alsina
Summary The concept of selective estrogen receptor modulators (SERMs) has emerged recently in modern medicine. Two main features, the evidence of the wide expression of estrogen receptors in organs and systems and the growing information on the determinants of estrogen action, have allowed the envisioning of compounds with "a la carte" estrogenic profiles. The availability of substances performing as agonists wherever the estrogenic action is beneficial and as antagonists where it is not, is becoming less of a dream than of a closer reality. This book is an up-to-date review of the principal basic mechanisms and the clinical data integrating the actual current knowledge on SERMs
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
In Springer e-books
Subject Selective estrogen receptor modulators.
Menopause -- Hormone therapy.
Estrogen -- Antagonists.
Estrogen -- Receptors.
Selective Estrogen Receptor Modulators -- pharmacology
Selective Estrogen Receptor Modulators -- therapeutic use
Estrogen Antagonists
Receptors, Estrogen
Selective Estrogen Receptor Modulators
MEDICAL -- Reproductive Medicine & Technology.
HEALTH & FITNESS -- Women's Health.
Menopause -- Hormone therapy.
Estrogen -- Antagonists.
Selective Estrogen Receptor Modulators -- pharmacology.
Selective Estrogen Receptor Modulators -- therapeutic use.
Estrogen Antagonists.
Receptors, Estrogen.
Selective estrogen receptor modulators.
Estrogen -- Antagonists.
Menopause -- Hormone therapy.
Selective estrogen receptor modulators.
Selektiver Östrogen-Rezeptor-Modulator
Genre/Form Aufsatzsammlung.
Form Electronic book
Author Sanchez, Antonio Cano.
Calaf i Alsina, Joaquim.
Dueñas-Díez, José-Luis.
ISBN 3540242279