Title Interstitial fibrosis in heart failure / edited by Francisco J. Villarreal

Published New York : Springer, ©2005

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Description 1 online resource (xiv, 373 pages) : illustrations Series Developments in cardiovascular medicine ; v. 253 Developments in cardiovascular medicine ; v. 253. Contents The Architecture of the Heart: Myocyte Organization and the Cardiac Extracellular Matrix; Extracellular Matrix and Cardiac Remodeling; Pro-Inflammatory Cytokines and Cardiac Extracellular Matrix: Regulation of Fibroblast Phenotype; Pharmacology of G-Protein-linked Signaling in Cardiac Fibroblasts; Serum Markers of Fibrillar Collagen Metabolism in Cardiac Diseases; Ultrasonic Characterization of the Myocardium; The Mechanics of the Fibrosed/Remodeled Heart; Renin Angiotensin Aldosterone System and Cardiac Extracellular Matrix; Matrix Metalloproteinases and Myocardial Remodeling; Cardiac Mast Cells as Mediators of Ventricular RemodelingTurmoil in the Cardiac Myocyte: Acute Intracellular Activation of Matrix Metalloproteinases; Regulation of Cardiac Extracellular Matrix Remodeling Following Myocardial Infarction.; Experimental Models of MMP Activation: Ventricular Volume Overload; Targets for Pharmacological Modulation of Cardiac Fibrosis; Biological and Functional Effects of Chronic Mechanical Support Induced by Left Ventricular Assist Devices on Failing Human Myocardium; Molecular Strategies for the Prevention of Cardiac Fibrosis; Prospects for Gene Therapy for the Fibrosed Heart: Targeting Regulators of Extracellular Matrix Turnover; Therapeutic Potential of TIMPs in Heart Failure Summary "Interstitial Fibrosis in Heart Failure provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis." "This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment."--Jacket Bibliography Includes bibliographical references and index Notes English Print version record In Springer e-books Subject Heart -- Fibrosis. Tissue remodeling. Heart failure. Endomyocardial Fibrosis Extracellular Matrix Proteins Heart Failure -- complications Matrix Metalloproteinases -- physiology Heart Failure HEALTH & FITNESS -- Diseases -- Heart. MEDICAL -- Cardiology. Tissue remodeling. Heart failure. Endomyocardial Fibrosis. Extracellular Matrix Proteins. Heart Failure, Congestive -- complications. Matrix Metalloproteinases -- physiology. Heart -- Fibrosis. Heart failure Heart -- Fibrosis Tissue remodeling Genre/Form Electronic books Form Electronic book Author Villarreal, Francisco J LC no. 2004052912 ISBN 038722825X 9780387228259 0387228241 9780387228242 661041162X 9786610411627 1280411627 9781280411625

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